Chimica | BIOLOGICAL CHEMISTRY

cod. 0522300004

BIOLOGICAL CHEMISTRY

	0522300004
	DIPARTIMENTO DI CHIMICA E BIOLOGIA "ADOLFO ZAMBELLI"

	CHEMISTRY
	2014/2015

PERCORSO COMUNE

	OBBLIGATORIO
	YEAR OF COURSE 1
	YEAR OF DIDACTIC SYSTEM 2010
	SECONDO SEMESTRE

TEACHING UNITS

	SSD	CFU	HOURS	ACTIVITY	TYPE OF ACTIVITY
	BIO/10	6	48	LESSONS	COMPULSORY SUBJECTS, CHARACTERISTIC OF THE CLASS

	Objectives
	LEARNING OUTCOMES AND COMPETENCE TO BE ACQUIRED: THE COURSE AIMS TO PROVIDE KNOWLEDGE ON THE STRUCTURE AND FUNCTION OF THE MAJOR BIOMOLECULES AND ON THE MAIN STREETS OF THE ENERGY METABOLISM, SUCH KNOWLEDGE IS ESSENTIAL TO THE UNDERSTANDING OF THE BIOLOGICAL ROLE AND USE IN THE FIELD OF BIOCHEMICAL TECHNIQUES USED IN INDUSTRY. KNOWLEDGE AND UNDERSTANDING: ACQUISITION OF THE SPECIFIC LANGUAGE IN THE SECTOR AND OF THE BASIC PRINCIPLES OF THE DISCIPLINE; APPLYING KNOWLEDGE AND UNDERSTANDING: BE ABLE TO ASSESS IN AN INDEPENDENT AND CRITICAL WAY ANY DIFFERENT OPINIONS EXIST IN CERTAIN TOPICS ADDRESSED DURING THE LESSONS; MAKING JUDGEMENTS: ABILITY TO DISCUSS IN A CRITICAL AND AUTONOMOUS WAY, TOPICS COVERED IN THE COURSE. COMMUNICATION SKILLS: STUDENTS HAVE TO INTERACT WITH EXPERTS FROM OTHER DISCIPLINES IN THE FIELD, TO COMMUNICATE THE RESULTS OF THEIR LEARNING EFFECTIVELY.

LEARNING OUTCOMES AND COMPETENCE TO BE ACQUIRED:
THE COURSE AIMS TO PROVIDE KNOWLEDGE ON THE STRUCTURE AND FUNCTION OF THE MAJOR BIOMOLECULES AND ON THE MAIN STREETS OF THE ENERGY METABOLISM, SUCH KNOWLEDGE IS ESSENTIAL TO THE UNDERSTANDING OF THE BIOLOGICAL ROLE AND USE IN THE FIELD OF BIOCHEMICAL TECHNIQUES USED IN INDUSTRY.
KNOWLEDGE AND UNDERSTANDING:
ACQUISITION OF THE SPECIFIC LANGUAGE IN THE SECTOR AND OF THE BASIC PRINCIPLES OF THE DISCIPLINE;
APPLYING KNOWLEDGE AND UNDERSTANDING:
BE ABLE TO ASSESS IN AN INDEPENDENT AND CRITICAL WAY ANY DIFFERENT OPINIONS EXIST IN CERTAIN TOPICS ADDRESSED DURING THE LESSONS;
MAKING JUDGEMENTS:
ABILITY TO DISCUSS IN A CRITICAL AND AUTONOMOUS WAY, TOPICS COVERED IN THE COURSE.
COMMUNICATION SKILLS:
STUDENTS HAVE TO INTERACT WITH EXPERTS FROM OTHER DISCIPLINES IN THE FIELD, TO COMMUNICATE THE RESULTS OF THEIR LEARNING EFFECTIVELY.

	Prerequisites
	KNOWLEDGE OF BASIC CONCEPTS OF BIOLOGY AND ORGANIC CHEMISTRY

	Contents
	METABOLISM. GENERAL MEANING OF INTERMEDIATE METABOLISM AND THE VARIOUS METABOLIC PATHWAYS (ANABOLIC, CATABOLIC, AMPHIBOLIC). MAIN MECHANISMS OF METABOLIC REGULATION: REGULATION OF ENZYME ACTIVITY, INHIBITION, ALLOSTERIC PROTEINS, REGULATORY ENZYMES, FEEDBACK REGULATION, COVALENT MODIFICATIONS, CASCADE CONTROL, ZYMOGENS. ISOENZYMES: CONCEPT AND PHYSIOLOGICAL SIGNIFICANCE. CATALYTIC STRATEGIES: SERINE PROTEASES MODEL. REGULATORY STRATEGIES: THE HEMOGLOBIN MODEL. CARBOHYDRATE METABOLISM:. METABOLISM OF DISACCHARIDES. GLYCOLYSIS. THE FATE OF PYRUVATE. THE PENTOSE PHOSPHATE PATHWAY. GLUCONEOGENESIS. GLYCOGEN METABOLISM. LIPID METABOLISM: ENZYMATIC DEGRADATION OF TRIACYLGLYCEROLS. BIOSYNTHESIS AND CATABOLISM OF FATTY ACIDS. KETONE BODIES. TERMINAL METABOLISM. THE CITRIC ACID CYCLE: REACTIONS AND REGULATION, ENERGY BALANCE. NATURE OF AMPHIBOLIC CYCLE: ANAPLEROTIC REACTIONS. BIOLOGICAL OXIDATIONS AND REDUCTIONS. THE ELECTRON TRANSPORT CHAIN. MECHANISM OF FAD AND NAD-DEPENDENT DEHYDROGENASE ACTION. THE OXIDATIVE PHOSPHORYLATION. METABOLISM OF AMINO ACIDS AND PROTEINS. METABOLIC FATE OF AMINO GROUPS: OXIDATIVE DEAMINATION, TRANSAMINATION AND DECARBOXYLATION REACTIONS. SUPERIOR ARCHITECTURE OF BIOLOGICAL MEMBRANES: PROTEOGLYCANS OF THE CELLULAR MATRIX. THE GLYCOLIPIDS OF THE MEMBRANE. INTEGRATION OF METABOLISM AND HORMONAL REGULATION: MOLECULAR MECHANISMS OF SIGNAL TRANSDUCTION.

Contents

METABOLISM.
GENERAL MEANING OF INTERMEDIATE METABOLISM AND THE VARIOUS METABOLIC PATHWAYS (ANABOLIC, CATABOLIC, AMPHIBOLIC). MAIN MECHANISMS OF METABOLIC REGULATION: REGULATION OF ENZYME ACTIVITY, INHIBITION, ALLOSTERIC PROTEINS, REGULATORY ENZYMES, FEEDBACK REGULATION, COVALENT MODIFICATIONS, CASCADE CONTROL, ZYMOGENS. ISOENZYMES: CONCEPT AND PHYSIOLOGICAL SIGNIFICANCE.
CATALYTIC STRATEGIES: SERINE PROTEASES MODEL.
REGULATORY STRATEGIES: THE HEMOGLOBIN MODEL.
CARBOHYDRATE METABOLISM:. METABOLISM OF DISACCHARIDES. GLYCOLYSIS. THE FATE OF PYRUVATE. THE PENTOSE PHOSPHATE PATHWAY. GLUCONEOGENESIS. GLYCOGEN METABOLISM.
LIPID METABOLISM: ENZYMATIC DEGRADATION OF TRIACYLGLYCEROLS. BIOSYNTHESIS AND CATABOLISM OF FATTY ACIDS. KETONE BODIES.
TERMINAL METABOLISM. THE CITRIC ACID CYCLE: REACTIONS AND REGULATION, ENERGY BALANCE. NATURE OF AMPHIBOLIC CYCLE: ANAPLEROTIC REACTIONS.
BIOLOGICAL OXIDATIONS AND REDUCTIONS. THE ELECTRON TRANSPORT CHAIN. MECHANISM OF FAD AND NAD-DEPENDENT DEHYDROGENASE ACTION. THE OXIDATIVE PHOSPHORYLATION.
METABOLISM OF AMINO ACIDS AND PROTEINS. METABOLIC FATE OF AMINO GROUPS: OXIDATIVE DEAMINATION, TRANSAMINATION AND DECARBOXYLATION REACTIONS.
SUPERIOR ARCHITECTURE OF BIOLOGICAL MEMBRANES: PROTEOGLYCANS OF THE CELLULAR MATRIX. THE GLYCOLIPIDS OF THE MEMBRANE.
INTEGRATION OF METABOLISM AND HORMONAL REGULATION: MOLECULAR MECHANISMS OF SIGNAL TRANSDUCTION.