Chimica | MECHANISMS OF REACTIONS IN ORGANIC CHEMISTRY

cod. 0522300015

MECHANISMS OF REACTIONS IN ORGANIC CHEMISTRY

	0522300015
	DIPARTIMENTO DI CHIMICA E BIOLOGIA "ADOLFO ZAMBELLI"

	CHEMISTRY
	2015/2016

PERCORSO COMUNE

	YEAR OF DIDACTIC SYSTEM 2010
	PRIMO SEMESTRE

TEACHING UNITS

	SSD	CFU	HOURS	ACTIVITY	TYPE OF ACTIVITY
	CHIM/06	6	48	LESSONS	SUPPLEMENTARY COMPULSORY SUBJECTS

	Objectives
	THE MAIN GOAL IS TO FURNISH TO THE STUDENT THE TOOLS FOR THE COMPREHENSION AND THE DISSERTATION OF THE REACTION MECHANISMS IN ORGANIC CHEMISTRY, WITH PARTICULAR ATTENTION TO THE INFLUENCE OF THE REACTION MEDIUM, CONDITIONS AND CATALYSTS USED. STUDENTS WILL ACQUIRE APPROPRIATE TOOLS TO INDAGATE THE REACTION MECHANISM FOR AN ORGANIC REACTION BOTH WITH KINETIC METHODS AND SPECTROSCOPIC TECHNIQUES

	Prerequisites
	KNOWLEDGE OF THE ARGUMENTS DEVELOPED IN THE FOUNDAMENTAL ORGANIC CHEMISTRY COURSES

	Contents
	FUNDAMENTAL PRINCIPLES OF THERMODYNAMIC STABILITY AND CHEMICAL KINETICS. STOICHIOMETRY. REACTION RATE EXPRESSIONS. ORDER AND MOLECULARITY AND THEIR DETERMINATION. ARRHENIUS EQUATION. SOLVENT, SALT, ISOTOPIC AND TEMPERATURE EFFECTS. BASICITY AND NUCLEOPHILICITY. ELECTROPHILICITY. INDUCTIVE, RESONANCE AND STERIC EFFECTS. TRANSITION STATE THEORY HAMMOND'S POSTULATE. CURTIN–HAMMETT PRINCIPLE. LINEAR FREE ENERGY RELATIONSHI (HAMMET, TAFT, WINSTEIN-GRUNWALD AND SWAIN-SCOTT). HSAB PRINCIPLE. SPECIFIC VERSUS GENERAL ACID CATALYSIS. HETEROGENEOUS CATALYSIS. ENZIMATIC CATALYSIS. INTERMEDIATES. STEREOCHEMICAL ASPECTS. ELIMINATION MECHANISMS. EXAMPLES

FUNDAMENTAL PRINCIPLES OF THERMODYNAMIC STABILITY AND CHEMICAL KINETICS. STOICHIOMETRY. REACTION RATE EXPRESSIONS. ORDER AND MOLECULARITY AND THEIR DETERMINATION. ARRHENIUS EQUATION. SOLVENT, SALT, ISOTOPIC AND TEMPERATURE EFFECTS. BASICITY AND NUCLEOPHILICITY. ELECTROPHILICITY. INDUCTIVE, RESONANCE AND STERIC EFFECTS. TRANSITION STATE THEORY HAMMOND'S POSTULATE. CURTIN–HAMMETT PRINCIPLE. LINEAR FREE ENERGY RELATIONSHI (HAMMET, TAFT, WINSTEIN-GRUNWALD AND SWAIN-SCOTT). HSAB PRINCIPLE. SPECIFIC VERSUS GENERAL ACID CATALYSIS. HETEROGENEOUS CATALYSIS. ENZIMATIC CATALYSIS. INTERMEDIATES. STEREOCHEMICAL ASPECTS. ELIMINATION MECHANISMS. EXAMPLES

	Teaching Methods
	LECTURES

	Verification of learning
	ORAL EXAMINATION

	Texts
	1) LOWRY, D. S. RICHARDSON, MECHANISM AND THEORY IN ORGANIC CHEMISTRY, 2) CAREY –SUNDBERG PART A ADVANCED ORGANIC CHEMISTRY 3) J. MARCH, ADVANCED ORGANIC CHEMISTRY- REACTIONS MECHANISM AND STRUCTURE. LECTURES NOTES