BIOINORGANIC CHEMISTRY

Chimica BIOINORGANIC CHEMISTRY

0522300055
DEPARTMENT OF CHEMISTRY AND BIOLOGY "ADOLFO ZAMBELLI"
EQF7
CHEMISTRY
2022/2023

OBBLIGATORIO
YEAR OF COURSE 1
YEAR OF DIDACTIC SYSTEM 2016
SPRING SEMESTER
CFUHOURSACTIVITY
648LESSONS
ExamDate
CHIMICA BIOINORGANICA15/02/2023 - 09:30
Objectives
THE COURSE WILL DISCUSS WHY A FEW INORGANIC ELEMENTS ARE NECESSARY IN LIVING ORGANISMS, TOGETHER WITH THEIR AVAILABILITY TO THE LATTER. IT WILL ALSO EXAMINE THE DIFFERENT TYPES OF COMPLEXES BETWEEN METALS AND BIOLOGICAL MOLECULES, AS WELL AS THE MECHANISM OF ACTION OF BIOLOGICAL PROCESSES INVOLVING INORGANIC ELEMENTS. FINALLY, THE COURSE WILL INTRODUCE THE MOST ADVANCED RESEARCH TOPICS IN THE FIELD OF BIOINORGANIC CHEMISTRY, E.G. METALLIC COMPLEXES CONJUGATED WITH POLYMERS AND THEIR USAGE IN DIAGNOSTIC AND CLINIC.
THE MAIN ACQUIRED KNOWLEDGE WILL BE:
• ESSENTIAL INORGANIC ELEMENTS FOR LIFE
• BIOLOGICAL PROCESSES THAT NEED METALS FOR ACTIVATION
• METAL COMPLEXES IN CLINICAL THERAPY AND DIAGNOSTICS
THE MAIN ABILITIES DEVELOPED BY THE STUDENT WILL BE:
• FORMATION OF METALLIC COMPLEXES TO SUPPLY ESSENTIAL ELEMENTS AND TO REMOVE TOXIC ELEMENTS
• SYNTHESIS OF METALLIC COMPLEXES WITH PHARMACOLOGICAL ABILITIES.
• SYNTHESIS OF METALLIC COMPLEXES FOR DIAGNOSTICS.
Prerequisites
NO PREREQUISITES
Contents
OVERVIEW OF BIOINORGANIC CHEMISTRY. WHAT IS BIOINORGANIC CHEMISTRY?
PRINCIPLE OF COORDINATION CHEMISTRY RELATED TO BIOINORGANIC CHEMISTRY. THE CHELATE EFFECT , PKA VALUES OF COORDINATED LIGANDS, LIGAND EXCHANGE RATES, ELECTRONIC AND GEOMETRIC STRUCTURES OF METAL IONS IN BIOLOGY.
PROPERTIES OF BIOLOGICAL MOLECULES. PROTEINS AND THEIR COSTITUENTS. PROTEINS AS LIGANDS. THE KINETIC ANALYSIS OF ENZYME REACTIONS. NUCLEIC ACIDS AND THEIR COSTITUENTS. RNA, DNA AND THEIR COSTITUENTS BLOCKS. METAL BINDING AND NUCLEIC ACID STRUCTURE. PROSTHETIC GROUPS.

UPTAKE OF METAL CONTAINING UNITS IN BIOLOGY. BIOAVAILABILITY OF METAL IONS. ENRICHMENT STRATEGIES AND INTRACELLULAR CHEMISTRY OF METALS. SPONTANEOUS SELF-ASSEMBLY OF METAL CLUSTERS.
CONTROL AND UTILIZATION OF METAL ION CONCENTRATION IN CELLS. AN EXAMPLE OF A BENEFICIAL METAL: IRON.

METAL ION STABILIZATION OF PROTEIN AND NUCLEIC ACID STRUCTURE. PROTEIN BINDING TO METALLATED DNA: MECHANISM OF ACTION OF FEW ANTICANCER AGENTS.

SELECTION AND INSERTION OF METAL IONS FOR PROTEIN SITES.
METAL FUNCTIONS IN METALLOPROTEINS. ELECTRON-TRANSFER PROTEINS. SUBSTRATE BINDING AND ACTIVATION BY NONREDOX MECHANISMS. ATOM- AND GROUP-TRANSFER CHEMISTRY. PROTEIN TUNING OF METAL PROPERTIES TO ACHIEVE SPECIFIC FUNCTIONS.

METALS IN MEDICINE. METAL COMPLEXES IN DIAGNOSIS AND CANCER THERAPY. SYNTHETIC POLYMERS AND BIOPOLYMERS AS CARRIERS OF METAL COMPLEXES: THE EPR EFFECT.
Teaching Methods
TEACHING THE COURSE INCLUDES 48 HOURS OF LECTURES TO BE HELD IN CLASSROOM. TEACHING SUPPORTS INCLUDES THE CLASSIC BLACKBOARD AND SLIDES USING THE POWER POINT PROGRAM.
ATTENDANCE OF LECTURES EX CATHEDRA ARE STRONGLY RECOMMENDED, ALSO WHY PARTS OF LESSONS REGARD RESEARCH TOPICS RECENTLY TREATED IN LITERATURE.
Verification of learning
ORAL EXAM (VIVA VOCE EXAM)
THE ORAL EXAMINATION SHOULD DETERMINE WHETHER THE STUDENT HAS ACQUIRED A DEEPER KNOWLEDGE OF THE FUNDAMENTAL CONCEPTS OF BIOINORGANIC CHEMISTRY AND OF THE MOST IMPORTANT MECHANISMS OF ACTION OF BIOLOGICAL PROCESSES INVOLVING INORGANIC ELEMENTS.
Texts
- HAND OUTS
- S.J. LIPPARD, J.M. BERG “PRINCIPLES OF BIOINORGANIC CHEMISTRY” - UNIVERSITY SCIENCE BOOKS.
- W. KAIM, B. SCHWEDERSKI “BIOINORGANIC CHEMISTRY: INORGANIC ELEMENTS IN THE CHEMISTRY OF LIFE” - WILEY
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