Farmacia | DRUG DELIVERY & CONTROLLED DOSAGE FORMS

cod. 0760100062

DRUG DELIVERY & CONTROLLED DOSAGE FORMS

	0760100062
	DIPARTIMENTO DI FARMACIA
	CORSO DI LAUREA MAGISTRALE A CICLO UNICO DI 5 ANNI
	FARMACIA
	2021/2022

PERCORSO COMUNE

	ANNO ORDINAMENTO 2016
	SECONDO SEMESTRE

MODULI

	SSD	CFU	ORE	ATTIVITÀ	TIPO DI ATTIVITÁ FORMATIVA
	CHIM/09	10	40	LEZIONE	AFFINE/INTEGRATIVA

	Obiettivi
	This core course introduces the fundamental mechanisms of pharmaceutical technology and factors underlying controlled drug delivery. Learning outcome: Student is able to explain the key points of controlled drug delivery and the factors affecting the rate of drug delivery. Student can classify different drug delivery systems and explain the theories behind them, compare different applications of each delivery system. Student is able to describe the drug release characterization methods and explain different manufacturing methods. Student can design an improvement for existing drug delivery device and justify its improvements as well as analyze its future views in the field of drug delivery devices.

This core course introduces the fundamental mechanisms of pharmaceutical technology and factors underlying controlled drug delivery. Learning outcome: Student is able to explain the key points of controlled drug delivery and the factors affecting the rate of drug delivery. Student can classify different drug delivery systems and explain the theories behind them, compare different applications of each delivery system. Student is able to describe the drug release characterization methods and explain different manufacturing methods. Student can design an improvement for existing drug delivery device and justify its improvements as well as analyze its future views in the field of drug delivery devices.

	Prerequisiti
	BASIC KNOWLEDGE OF INORGANIC AND ORGANIC CHEMISTRY, ANALITICAL CHEMISTRY, PHYSICAL CHEMISTRY AND PHARMACEUTICAL TECHNOLOGY.

	Contenuti
	- BASIC CONCEPTS RELATED TO THE CONTROLLED RELEASE OF THE DRUGS – (4 H) - SOLID PHARMACEUTICAL DOSAGE FORMS (MATRIX AND RESERVOIR SYSTEMS) – (4 H) - WETTING AND DISSOLUTION RATE OF PHARMACEUTICAL DOSAGE FORMS – (2 H) - FICK LAWS APPLIED TO DRUG RELEASE – (2 H) - MECHANISMS TO CONTROL DRUG RELEASE RATE FOR DIFFERENT ADMINISTRATION ROUTES – (2 H) - CONTROLLED DRUG RELEASE DOSAGE FORMS: RESERVOIR SYSTEMS. OSMOTIC PUMP. ENTERIC MATRICES. POLYMERIC SWELLING/EROSION SYSTEMS – (6 H) - CONTROLLED RELEASE DOSAGE FORMS MANUFACTURING METHODS – (4 H) - MICROPARTICLES FOR CONTROLLED DRUG RELEASE: CHARACTERIZATION BOTH IN VITRO AND IN VIVO – (4 H) - NANOPARTICLES FOR CONTROLLED DRUG RELEASE: CHARACTERIZATION BOTH IN VITRO AND IN VIVO – (2 H) - LIPOSOMES: MANUFACTURING METHODS AND CHARACTERIZATION BOTH IN VITRO AND IN VIVO – (2 H) - IMPLANTS FOR CONTROLLED DRUG DELIVERY – (4 H) - TRANSDERMAL DRUG DELIVERY SYSTEMS – (4 H)

Contenuti

- BASIC CONCEPTS RELATED TO THE CONTROLLED RELEASE OF THE DRUGS – (4 H)
- SOLID PHARMACEUTICAL DOSAGE FORMS (MATRIX AND RESERVOIR SYSTEMS) – (4 H)
- WETTING AND DISSOLUTION RATE OF PHARMACEUTICAL DOSAGE FORMS – (2 H)
- FICK LAWS APPLIED TO DRUG RELEASE – (2 H)
- MECHANISMS TO CONTROL DRUG RELEASE RATE FOR DIFFERENT ADMINISTRATION ROUTES – (2 H)
- CONTROLLED DRUG RELEASE DOSAGE FORMS: RESERVOIR SYSTEMS. OSMOTIC PUMP. ENTERIC MATRICES. POLYMERIC SWELLING/EROSION SYSTEMS – (6 H)
- CONTROLLED RELEASE DOSAGE FORMS MANUFACTURING METHODS – (4 H)
- MICROPARTICLES FOR CONTROLLED DRUG RELEASE: CHARACTERIZATION BOTH IN VITRO AND IN VIVO – (4 H)
- NANOPARTICLES FOR CONTROLLED DRUG RELEASE: CHARACTERIZATION BOTH IN VITRO AND IN VIVO – (2 H)
- LIPOSOMES: MANUFACTURING METHODS AND CHARACTERIZATION BOTH IN VITRO AND IN VIVO – (2 H)
- IMPLANTS FOR CONTROLLED DRUG DELIVERY – (4 H)
- TRANSDERMAL DRUG DELIVERY SYSTEMS – (4 H)

	Metodi Didattici
	FRONTAL LESSONS, INTERACTIVE LEARNING AND LAB EXPERIENCE. FRONTAL LESSONS ARE CONDUCTED BY MULTIMEDIA PRESENTATIONS. THE OPTIONAL LAB EXPERINCES ARE CONDUCTED INTO A LABORATORY DEDICATED TO THE PHARMACEUTICAL TECHNOLOGY, ALLOW TO APPLY THE LEARNED THEORETICAL NOTIONS TO THE PREPARATION OF CONTROLLED DRUG RELEASE FORMULATIONS

	Verifica dell'apprendimento
	ORAL EXAMINATION ORAL EXAMINATION CONSISTS OF A DISCUSSION OF APPROXIMATELY 20 MINUTES, TO VERIFY THE COMPREHENSION OF THE ARGUMENTS SUBJECT TO THE COURSE AND THE ABILITY TO SOLVE PROBLEMS RELATED TO THE FORMULATION OF INNOVATIVE PHARMACEUTICAL DOSAGE FORMS

	Testi
	COLOMBO P., CATELLANI P. L., GAZZANIGA A., MENEGATTI E., VIDALE E., PRINCIPI DI TECNOLOGIE FARMACEUTICHE, ED. AMBROSIANA, 2004 WISE D. L., HANDBOOK OF PHARMACEUTICAL CONTROLLED RELEASE TECHNOLOGY, M. DEKKER, 2000 LI X., DESIGN OF CONTROLLED RELEASE DRUG DELIVERY SYSTEMS, MCGRAW-HILL, 2005 WILSON C. G., CROWLEY P. J., CONTROLLED RELEASE IN ORAL DRUG DELIVERY, SPRINGER, 2011