Midwifery | General Pathology and Microbiology

cod. 1012400007

GENERAL PATHOLOGY AND MICROBIOLOGY

	1012400007
	DIPARTIMENTO DI MEDICINA, CHIRURGIA E ODONTOIATRIA "SCUOLA MEDICA SALERNITANA"

	MIDWIFERY
	2013/2014

PERCORSO COMUNE

	OBBLIGATORIO
	YEAR OF COURSE 1
	YEAR OF DIDACTIC SYSTEM 2013
	SECONDO SEMESTRE

TEACHING UNITS

	SSD	CFU	HOURS	ACTIVITY	TYPE OF ACTIVITY
1	PATOLOGIA GENERALE E MICROBIOLOGIA - MOD 1
	MED/04	2	24	LESSONS	BASIC COMPULSORY SUBJECTS
2	PATOLOGIA GENERALE E MICROBIOLOGIA - MOD 2
	MED/05	1	12	LESSONS	COMPULSORY SUBJECTS, CHARACTERISTIC OF THE CLASS
3	PATOLOGIA GENERALE E MICROBIOLOGIA - MOD 3
	MED/07	1	12	LESSONS	BASIC COMPULSORY SUBJECTS
4	PATOLOGIA GENERALE E MICROBIOLOGIA - MOD 4
	MED/46	1	12	LESSONS	SUPPLEMENTARY COMPULSORY SUBJECTS

PROFESSORS

	MAURIZIO BIFULCO1 T Curriculum
	LUIGI SORRENTINO2 Curriculum
	EMILIA VACCARO3 Curriculum
	ANGELO MASSARI4 Curriculum

	Objectives
	THE STUDENT WILL LEARN THE MECHANISMS BY WHICH THE VARIOUS AGENTS CAUSING ILLNESS INTERACT WITH BIOLOGICAL SYSTEMS AND THEREBY INDUCE DAMAGE AND ALTERATIONS IN THE STRUCTURE AND FUNCTIONS OF CELLS, TISSUES AND ORGANS, DISRUPTING THE HOMEOSTATIC BALANCE AND CAUSING ILLNESS ONSET AND PROGRESSION. TO THIS END, THE CONCEPTUAL BASES FOR UNDERSTANDING THE CAUSES OF DISEASES IN HUMANS WILL BE PROVIDED, TOGETHER WITH GENERAL PATHOGENIC MECHANISMS AND PATHOPHYSIOLOGICAL PROCESSES AFFECTING CELLS, APPARATA AND SYSTEMS. UPON COMPLETION OF THE COURSE, THE STUDENT WILL BE ABLE TO ANALYZE, IDENTIFY AND INTERPRET THE PATHOGENIC MECHANISMS THAT CAUSE HUMAN DISEASES AND THEIR CONSEQUENCES, AND MUST HAVE ACQUIRED BASIC INFORMATION ON THE MAIN DIAGNOSTIC TECHNIQUES.

THE STUDENT WILL LEARN THE MECHANISMS BY WHICH THE VARIOUS AGENTS CAUSING ILLNESS INTERACT WITH BIOLOGICAL SYSTEMS AND THEREBY INDUCE DAMAGE AND ALTERATIONS IN THE STRUCTURE AND FUNCTIONS OF CELLS, TISSUES AND ORGANS, DISRUPTING THE HOMEOSTATIC BALANCE AND CAUSING ILLNESS ONSET AND PROGRESSION. TO THIS END, THE CONCEPTUAL BASES FOR UNDERSTANDING THE CAUSES OF DISEASES IN HUMANS WILL BE PROVIDED, TOGETHER WITH GENERAL PATHOGENIC MECHANISMS AND PATHOPHYSIOLOGICAL PROCESSES AFFECTING CELLS, APPARATA AND SYSTEMS. UPON COMPLETION OF THE COURSE, THE STUDENT WILL BE ABLE TO ANALYZE, IDENTIFY AND INTERPRET THE PATHOGENIC MECHANISMS THAT CAUSE HUMAN DISEASES AND THEIR CONSEQUENCES, AND MUST HAVE ACQUIRED BASIC INFORMATION ON THE MAIN DIAGNOSTIC TECHNIQUES.

	Prerequisites
	BASIC ANATOMY AND HISTOLOGY, BIOLOGY AND BIOCHEMISTRY, PHYSICS, PHYSIOLOGY. IN PARTICULAR, DETAILED KNOWLEDGE OF THE STRUCTURE AND FUNCTIONS OF EUKARYOTIC CELLS, TISSUES, ORGANS AND SYSTEMS; DEVELOPMENT AND SEXUAL DETERMINATION; DNA AND CHROMOSOME ORGANIZATION, RNA AND PROTEINS.

	Contents
	THE CONCEPT OF DISEASE: THE DISEASE, AS LOSS OF THE HEALTH STATUS AND HOMEOSTATIC UNBALANCE. ETIOLOGY: THE CONCEPT OF "CAUSE" IN PATHOLOGY. PATHOGENESIS: KEY PATHOGENIC MECHANISMS. PATHOLOGY GENOMICS: THE GENOME AS A CAUSE OF DISEASE, CONGENITAL AND HEREDITARY GENOMIC, CHROMOSOMAL AND GENE MUTATIONS; DISEASES RELATED TO MUTATIONS OF MITOCHONDRIAL DNA. GENOME INSTABILITY. CELL INJURY, CELL DEATH (NECROSIS AND APOPTOSIS) AND ADAPTATION INFLAMMATION AND REPAIR: ACUTE AND CHRONIC INFLAMMATION; FEVER IMMUNE SYSTEM: INNATE AND ADAPTIVE IMMUNITY; AUTOIMMUNITY; IMMUNOPATHOLOGY GENERAL ONCOLOGY: THE CONCEPT OF NEOPLASIA; PHYSIOLOGICAL AND PATHOLOGICAL PROLIFERATIONS; HISTOGENETIC AND CLINICAL CLASSIFICATION OF NEOPLASMS, BENIGNITY AND MALIGNANCY; THE CONCEPT OF TUMOR PROGRESSION, ANGIOGENESIS, INFILTRATIVE GROWTH. METASTASIS: DEFINITION AND GENERAL CONCEPTS; PROTO-ONCOGENES AND TUMOR SUPPRESSOR GENES.

Contents

THE CONCEPT OF DISEASE: THE DISEASE, AS LOSS OF THE HEALTH STATUS AND HOMEOSTATIC UNBALANCE. ETIOLOGY: THE CONCEPT OF "CAUSE" IN PATHOLOGY. PATHOGENESIS: KEY PATHOGENIC MECHANISMS.
PATHOLOGY GENOMICS: THE GENOME AS A CAUSE OF DISEASE, CONGENITAL AND HEREDITARY GENOMIC, CHROMOSOMAL AND GENE MUTATIONS; DISEASES RELATED TO MUTATIONS OF MITOCHONDRIAL DNA. GENOME INSTABILITY.

CELL INJURY, CELL DEATH (NECROSIS AND APOPTOSIS) AND ADAPTATION

INFLAMMATION AND REPAIR: ACUTE AND CHRONIC INFLAMMATION; FEVER

IMMUNE SYSTEM: INNATE AND ADAPTIVE IMMUNITY; AUTOIMMUNITY; IMMUNOPATHOLOGY

GENERAL ONCOLOGY: THE CONCEPT OF NEOPLASIA; PHYSIOLOGICAL AND PATHOLOGICAL PROLIFERATIONS; HISTOGENETIC AND CLINICAL CLASSIFICATION OF NEOPLASMS, BENIGNITY AND MALIGNANCY; THE CONCEPT OF TUMOR PROGRESSION, ANGIOGENESIS, INFILTRATIVE GROWTH. METASTASIS: DEFINITION AND GENERAL CONCEPTS; PROTO-ONCOGENES AND TUMOR SUPPRESSOR GENES.

	Teaching Methods
	FORMAL LECTURES AND INFORMAL COLLOQUIA WITH THE STUDENTS.

	Verification of learning
	ORAL EXAMINATION

	Texts
	- G.M. PONTIERI ELEMENTI DI PATOLOGIA GENERALE, III EDIZ. CASA EDITRICE PICCIN -WOOLF (TRADUZ. M.BIFULCO & B. MONCHARMONT) PATOLOGIA GENERALE – MECCANISMI DELLA MALATTIA, IDELSON-GNOCCHI