C.I. CHIMICA E PROPEDEUTICA BIOCHIMICA

Dentistry C.I. CHIMICA E PROPEDEUTICA BIOCHIMICA

1060200003
DIPARTIMENTO DI MEDICINA, CHIRURGIA E ODONTOIATRIA "SCUOLA MEDICA SALERNITANA"
EQF7
DENTISTRY
2016/2017

OBBLIGATORIO
YEAR OF COURSE 1
YEAR OF DIDACTIC SYSTEM 2015
SECONDO SEMESTRE
CFUHOURSACTIVITY
1C.I. CHIMICA E PROPEDEUTICA BIOCHIMICA - MOD. CHIMICA
666LESSONS
2C.I. CHIMICA E PROPEDEUTICA BIOCHIMICA - MOD. CHIMICA FARMACEUTICA
111LESSONS
3C.I. CHIMICA E PROPEDEUTICA BIOCHIMICA - FARMACEUTICO TECNOLOGICO APPLICATIVO
111LESSONS
Objectives
STUDENTS WILL DEVELOP THE FOLLOWING SKILLS:
- TO ACQUIRE THE NECESSARY BASIC KNOWLEDGE OF CHEMISTRY FOR ANALYSING MOLECULES AND MECHANISMS OF BIOMEDICAL INTEREST;
- TO KNOW STRUCTURE AND FUNCTION OF THE MAIN MOLECULES OF BIOMEDICAL INTEREST;
- TO BE ABLE TO UNDERSTAND AT THE MOLECULAR LEVEL THE PROCESSES DESCRIBED BY BIOMEDICAL SCIENCES TEACHED IN THE FOLLOWING YEARS OF STUDIES
- TO KNOW THE CHEMISTRY OF THE MAIN POLYMERIZATION REACTIONS AND THE STRUCTURAL FEATURES OF SOME NATURAL AND SYNTHETIC POLYMERS
- TO APPLY THE CHEMISTRY KNOWLEDGE ACHIEVED TO UNDERSTAND THE ROLE OF THE CHEMICAL PROPERTIES OF DRUGS IN IN THE DETERMINATION OF THEIR ACTION
Prerequisites
BASIC KNOWLEDGES OF MATHEMATICS, PHYSICS AND BIOLOGY
Contents
TEACHING MODULE: CHEMISTRY (BIO10)
ATOMS AND MOLECULES: STRUCTURE, PROPERTIES AND THEIR IMPORTANCE IN MEDICINE. THE ATOMIC STRUCTURE AND THE PERIODIC TABLE OF ELEMENTS. ELEMENTS IN BIOMOLECULES AND THEIR FUNCTION REGULATION. CHEMICAL BONDS; ELECTRONEGATIVITY OF ELEMENTS AND POLARITY OF MOLECULES. MOLECULAR GEOMETRY. RADIOISOTOPES AND RADIOACTIVE DECAY. BASIC ELEMENTS OF SPECTROSCOPY (FLUORESCENCE, FOSFORESCENCE, MAGNETIC RESONANCE). DIAGNOSTIC APPLICATION IN MEDICINE AND IN BIOMEDICAL RESEARCH. QUANTITATIVE AND ENERGETIC RELATIONS IN CHEMICAL REACTIONS: THEORIC BASES TO UNDERSTAND THE METABOLISM. OXIDATION STATE. REDOX REACTIONS. MOLECULAR WEIGHT. THE MOLE. STOICHIOMETRY. STATES OF MATTER AND PHASE TRANSITIONS. GASES LAW. GAS EXCHANGE IN PULMONARY VENTILATION. TERMODYNAMIC FUNCTIONS AND THEIR CHANGES IN CHEMICAL TRANSFORMATIONS. LIVING ORGANISMS AS OPEN THERMODYNAMIC SYSTEMS. CHEMICAL REACTIONS IN THE METABOLISM: CATABOLISM AND ANABOLISM. CHEMICAL KINETICS: ACTIVATION ENERGY, RATE AND RATE CONSTANT OF CHEMICAL REACTIONS. REACTION ORDER. CATALYSIS. ENZYMES AS BIOLOGICAL CATALYSTS.
CHEMICAL EQUILIBRIUM, OSMOTIC PRESSURE AND PH. LAW OF MASS ACTION AND EQUILIBRIUM CONSTANT; PRINCIPLE OF MOBILE EQUILIBRIUM. SOLUTIONS, SOLUBILITY AND CONCENTRATION UNITS. COLLIGATIVE PROPERTIES. OSMOSIS, OSMOTIC PRESSURE AND THEIR BIOLOGICAL IMPORTANCE. ONCOTIC PRESSURE AND THE CORRECT DISTRIBUTION OF BODY FLUIDS INTO THE INTERVASCULAR COMPARTMENTS AND TISSUES. DIALYSIS AND ULTRAFILTRATION: BIOLOGICAL ASPECTS. ACIDS, BASES AND SALTS. ACID-BASE EQUILIBRIA IN AQUEOUS SOLUTIONS. WATER DISSOCIATION; THE PH. BUFFER SOLUTIONS. PH IN BODY FLUIDS: THE BUFFER SYSTEMS: RESPIRATORY AND RENAL MECHANISMS OF REGULATION. ACIDOSIS AND ALKALOSIS.
MOLECULES OF BIOLOGICAL INTEREST. THE CARBON; HYDROCARBURES; FUNCTIONAL GROUPS IN THE MAIN MOLECULES OF BIOCHEMICAL INTEREST. STEREOCHEMISTRY. CARBOHYDRATES: MONOSACCHARIDES, OLIGOSACCHARIDES, POLYSACCHARIDES; THEIR ROLE IN THE STRUCTURES OF THE TISSUES AND CELL CONSTITUENTS. LIPIDS: GENERAL ASPECTS AND CLASSIFICATION. FATTY ACIDS. TRIACYLGLYCEROLS. PHOSPHOLIPIDS. STEROIDS: CHOLESTEROL, BILIARY ACIDS, STEROID HORMONES. AMINOACIDS: STRUCTURE AND PROPERTIES. PEPTIDE BOND. OLIGOPEPTIDES AND POLYPEPTIDES. SOME RELEVANT PEPTIDES IN HUMAN PHYSIOPATHOLOGY: PEPTIDE HORMONES; NEUROPEPTIDES; GLUTATHION. PROTEINS AND THEIR STRUCTURAL LEVELS; PROTEIN DOMAINS; PROTEIN FAMILIES. NUCLEOSIDES. PURINES AND PIRIMIDINES IN NUCLEOTIDES. ADENOSINE TRIPHOSPHATE (ATP) AND ITS FUNTION IN THE CATABOLISM AND ANABOLISM CONNECTION. NUCLEIC ACIDS.

TEACHING MODULE: PHARMACEUTICAL TECHNOLOGICAL APPLICATIONS (CHIM09)
SYNTHETIC (POLYESTERS, POLYURETHANES, POLYACRYLATES AND POLYVINYLS) AND NATURAL (POLYSACCHARIDES, GUMS, POLYAMIDES) POLYMERS: CHEMISTRY OF THE POLYMERIZATION REACTIONS, AND CHEMICAL-PHYSIC FEATURES OF THE COMPOUNDS.

TEACHING MODULE: MEDICINAL CHEMISTRY (CHIM08)
SYNTHETIC (POLYESTERS, POLYURETHANES, POLYACRYLATES AND POLYVINYLS) AND NATURAL (POLYSACCHARIDES, GUMS, POLYAMIDES) POLYMERS: CHEMISTRY OF THE POLYMERIZATION REACTIONS, AND CHEMICAL-PHYSIC FEATURES OF THE COMPOUNDS.
Teaching Methods
LECTURES AND TUTORIALS
Verification of learning
WRITTEN AND ORAL EXAM
Texts
P. ATKINS, L. JONES, CHEMICAL PRINCIPLES: THE QUEST FOR INSIGHT. W.H. FREEMAN & CO.
J. MC MURRY, FUNDAMENTALS OF ORGANIC CHEMISTRY. BROOKS/COLE, A CENGAGE LEARNING COMPANY
J.M. BERG, J.L. TYMOCZKO, G.J. GATTO JR., L. STRYER, BIOCHEMISTRY. MCMILLAN.
More Information
FURTHER INFORMATION, PLEASE CONTACT THE TEACHERS: MARZULLO@UNISA.IT, SCASTELLANO@UNISA.IT, FDALPIAZ@UNISA.IT
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