Dentistry | C.I. CHIMICA E PROPEDEUTICA BIOCHIMICA

cod. 1060200003

C.I. CHIMICA E PROPEDEUTICA BIOCHIMICA

	1060200003
	DIPARTIMENTO DI MEDICINA, CHIRURGIA E ODONTOIATRIA "SCUOLA MEDICA SALERNITANA"
	EQF7
	DENTISTRY
	2020/2021

PERCORSO SHARED STUDY PATHWAY

	OBBLIGATORIO
	YEAR OF COURSE 1
	YEAR OF DIDACTIC SYSTEM 2015
	PRIMO SEMESTRE

TEACHING UNITS

	SSD	CFU	HOURS	ACTIVITY	TYPE OF ACTIVITY
1	C.I. CHIMICA E PROPEDEUTICA BIOCHIMICA - MOD. CHIMICA
	BIO/10	6	66	LESSONS	BASIC COMPULSORY SUBJECTS
2	C.I. CHIMICA E PROPEDEUTICA BIOCHIMICA - FARMACEUTICO TECNOLOGICO APPLICATIVO
	CHIM/09	2	22	LESSONS	SUPPLEMENTARY COMPULSORY SUBJECTS

PROFESSORS

	LIBERATO MARZULLO1 T Curriculum
	GIOVANNA DELLA PORTA2 Curriculum

	Objectives
	STUDENTS WILL DEVELOP THE FOLLOWING SKILLS: - TO ACQUIRE THE NECESSARY BASIC KNOWLEDGE OF CHEMISTRY FOR ANALYSING MOLECULES AND MECHANISMS OF BIOMEDICAL INTEREST; - TO KNOW STRUCTURE AND FUNCTION OF THE MAIN MOLECULES OF BIOMEDICAL INTEREST; - TO BE ABLE TO UNDERSTAND AT THE MOLECULAR LEVEL THE PROCESSES DESCRIBED BY BIOMEDICAL SCIENCES TEACHED IN THE FOLLOWING YEARS OF STUDIES - TO KNOW THE CHEMISTRY OF THE MAIN POLYMERIZATION REACTIONS AND THE STRUCTURAL FEATURES OF SOME NATURAL AND SYNTHETIC POLYMERS

STUDENTS WILL DEVELOP THE FOLLOWING SKILLS:
- TO ACQUIRE THE NECESSARY BASIC KNOWLEDGE OF CHEMISTRY FOR ANALYSING MOLECULES AND MECHANISMS OF BIOMEDICAL INTEREST;
- TO KNOW STRUCTURE AND FUNCTION OF THE MAIN MOLECULES OF BIOMEDICAL INTEREST;
- TO BE ABLE TO UNDERSTAND AT THE MOLECULAR LEVEL THE PROCESSES DESCRIBED BY BIOMEDICAL SCIENCES TEACHED IN THE FOLLOWING YEARS OF STUDIES
- TO KNOW THE CHEMISTRY OF THE MAIN POLYMERIZATION REACTIONS AND THE STRUCTURAL FEATURES OF SOME NATURAL AND SYNTHETIC POLYMERS

	Prerequisites
	ACCORDING TO SECTION 11 OF THE PUBLISHED DIDACTIC GUIDELINES

	Contents
	TEACHING MODULE: CHEMISTRY (BIO10) ATOMS AND MOLECULES: STRUCTURE, PROPERTIES AND THEIR IMPORTANCE IN MEDICINE. THE ATOMIC STRUCTURE AND THE PERIODIC TABLE OF ELEMENTS. THE ELEMENTS IN THE BIOMOLECULES. CHEMICAL BONDS; ELECTRONEGATIVITY OF ELEMENTS AND POLARITY OF MOLECULES. MOLECULAR GEOMETRY. RADIOISOTOPES AND RADIOACTIVE DECAY. BASIC ELEMENTS OF SPECTROSCOPY. DIAGNOSTIC APPLICATION IN MEDICINE AND IN BIOMEDICAL RESEARCH. OXIDATION STATE. RED-OX REACTIONS. MOLECULAR WEIGHT. THE MOLE. STOICHIOMETRY. STATES OF MATTER AND PHASE TRANSITIONS. GASES LAW. GAS EXCHANGE IN PULMONARY VENTILATION. TERMODYNAMIC FUNCTIONS AND THEIR CHANGES IN CHEMICAL TRANSFORMATIONS. LIVING ORGANISMS AS OPEN THERMODYNAMIC SYSTEMS. CHEMICAL KINETICS: ACTIVATION ENERGY, RATE AND RATE CONSTANT OF CHEMICAL REACTIONS. REACTION ORDER. CATALYSIS. ENZYMES AS BIOLOGICAL CATALYSTS. CHEMICAL EQUILIBRIUM, OSMOTIC PRESSURE AND PH. LAW OF MASS ACTION AND EQUILIBRIUM CONSTANT; PRINCIPLE OF MOBILE EQUILIBRIUM. SOLUTIONS, SOLUBILITY AND CONCENTRATION UNITS. COLLIGATIVE PROPERTIES. OSMOSIS, OSMOTIC PRESSURE AND THEIR BIOLOGICAL IMPORTANCE. ACIDS, BASES AND SALTS. ACID-BASE EQUILIBRIA IN AQUEOUS SOLUTIONS. WATER DISSOCIATION; THE PH. BUFFER SOLUTIONS. PH IN BODY FLUIDS: BUFFER SYSTEMS. MOLECULES OF BIOLOGICAL INTEREST. THE CARBON; HYDROCARBURES; FUNCTIONAL GROUPS IN THE MAIN MOLECULES OF BIOCHEMICAL INTEREST. STEREOCHEMISTRY. CARBOHYDRATES: MONOSACCHARIDES, OLIGOSACCHARIDES, POLYSACCHARIDES; THEIR ROLE IN THE STRUCTURES OF THE TISSUES AND CELL CONSTITUENTS. LIPIDS: GENERAL ASPECTS AND CLASSIFICATION. FATTY ACIDS. TRIACYLGLYCEROLS. PHOSPHOLIPIDS. STEROIDS: CHOLESTEROL, BILIARY ACIDS, STEROID HORMONES. AMINOACIDS: STRUCTURE AND PROPERTIES. PEPTIDE BOND. OLIGOPEPTIDES AND POLYPEPTIDES. SOME RELEVANT PEPTIDES IN HUMAN PHYSIOPATHOLOGY. NUCLEOSIDES. PURINES AND PIRIMIDINES IN NUCLEOTIDES. ADENOSINE TRIPHOSPHATE (ATP) AND ITS FUNTION IN THE CATABOLISM AND ANABOLISM CONNECTION. NUCLEIC ACIDS. TEACHING MODULE: PHARMACEUTICAL TECHNOLOGICAL APPLICATIONS (CHIM09) DEFINITION OF POLYMER, CO-POLYMER OMO-POLYMERS, THREE-DIMENSIONAL STRUCTURE, SUPRA-MOLECULAR STRUCTURE. EXAMPLE OF BIO-POLYMERS: DNA-RNA, STARCH/CELLULOSE, PROTEINS. POLYMERIZATION MECHANISMS: CONDENSATION (ESTER AND AMIDE BOND); RADICAL ADDITION (POLY-ETHYLENE, POLY-PROPYLENE, POLY-METHACRYLATE). RADICAL INITIATION: CHEMICAL AND UVVIS. CONFORMATION AND CONFIGURATION. TACTILITY. BIODEGRADABLE AND BIOCOMPATIBLE POLYMERS. BIODEGRADABLE SYNTHETIC POLYMERS: POLY-GLYCOLIC (PGA), POLY-LACTIC (PLA), POLY-LACTIC-CO-GLYCOLIC (PLGA), POLY-CAPROLACTONE (PCL). NATURAL POLYMERS: COLLAGEN, FIBRIN, ALGINATES, CHITOSAN. EXAMPLE OF PROSTHESIS AND ORTHODONTIC IMPLANTS. AMORPHOUS, SEMI-CRYSTALLINE AND CRYSTALLINE POLYMERS. DEGREE OF CRYSTALLINITY, DEGREE OF POLYMERIZATION, MOLECULAR WEIGHT DISTRIBUTION. MEASUREMENT OF POLYMER MOLECULAR WEIGHT. MECHANICAL PROPERTIES OF POLYMERS, DEFINITION OF ELASTIC MODULUS AND STRESS-STRAIN CURVE. VARIATION OF THE PHYSICAL STATE AS A FUNCTION OF TEMPERATURE; DEFINITION OF GLASS TRANSITION AND SOFTENING TEMPERATURE.

Contents

TEACHING MODULE: CHEMISTRY (BIO10)
ATOMS AND MOLECULES: STRUCTURE, PROPERTIES AND THEIR IMPORTANCE IN MEDICINE. THE ATOMIC STRUCTURE AND THE PERIODIC TABLE OF ELEMENTS. THE ELEMENTS IN THE BIOMOLECULES. CHEMICAL BONDS; ELECTRONEGATIVITY OF ELEMENTS AND POLARITY OF MOLECULES. MOLECULAR GEOMETRY. RADIOISOTOPES AND RADIOACTIVE DECAY. BASIC ELEMENTS OF SPECTROSCOPY. DIAGNOSTIC APPLICATION IN MEDICINE AND IN BIOMEDICAL RESEARCH. OXIDATION STATE. RED-OX REACTIONS. MOLECULAR WEIGHT. THE MOLE. STOICHIOMETRY. STATES OF MATTER AND PHASE TRANSITIONS. GASES LAW. GAS EXCHANGE IN PULMONARY VENTILATION. TERMODYNAMIC FUNCTIONS AND THEIR CHANGES IN CHEMICAL TRANSFORMATIONS. LIVING ORGANISMS AS OPEN THERMODYNAMIC SYSTEMS. CHEMICAL KINETICS: ACTIVATION ENERGY, RATE AND RATE CONSTANT OF CHEMICAL REACTIONS. REACTION ORDER. CATALYSIS. ENZYMES AS BIOLOGICAL CATALYSTS.
CHEMICAL EQUILIBRIUM, OSMOTIC PRESSURE AND PH. LAW OF MASS ACTION AND EQUILIBRIUM CONSTANT; PRINCIPLE OF MOBILE EQUILIBRIUM. SOLUTIONS, SOLUBILITY AND CONCENTRATION UNITS. COLLIGATIVE PROPERTIES. OSMOSIS, OSMOTIC PRESSURE AND THEIR BIOLOGICAL IMPORTANCE. ACIDS, BASES AND SALTS. ACID-BASE EQUILIBRIA IN AQUEOUS SOLUTIONS. WATER DISSOCIATION; THE PH. BUFFER SOLUTIONS. PH IN BODY FLUIDS: BUFFER SYSTEMS. MOLECULES OF BIOLOGICAL INTEREST. THE CARBON; HYDROCARBURES; FUNCTIONAL GROUPS IN THE MAIN MOLECULES OF BIOCHEMICAL INTEREST. STEREOCHEMISTRY. CARBOHYDRATES: MONOSACCHARIDES, OLIGOSACCHARIDES, POLYSACCHARIDES; THEIR ROLE IN THE STRUCTURES OF THE TISSUES AND CELL CONSTITUENTS. LIPIDS: GENERAL ASPECTS AND CLASSIFICATION. FATTY ACIDS. TRIACYLGLYCEROLS. PHOSPHOLIPIDS. STEROIDS: CHOLESTEROL, BILIARY ACIDS, STEROID HORMONES. AMINOACIDS: STRUCTURE AND PROPERTIES. PEPTIDE BOND. OLIGOPEPTIDES AND POLYPEPTIDES. SOME RELEVANT PEPTIDES IN HUMAN PHYSIOPATHOLOGY. NUCLEOSIDES. PURINES AND PIRIMIDINES IN NUCLEOTIDES. ADENOSINE TRIPHOSPHATE (ATP) AND ITS FUNTION IN THE CATABOLISM AND ANABOLISM CONNECTION. NUCLEIC ACIDS.

TEACHING MODULE: PHARMACEUTICAL TECHNOLOGICAL APPLICATIONS (CHIM09)
DEFINITION OF POLYMER, CO-POLYMER OMO-POLYMERS, THREE-DIMENSIONAL STRUCTURE, SUPRA-MOLECULAR STRUCTURE. EXAMPLE OF BIO-POLYMERS: DNA-RNA, STARCH/CELLULOSE, PROTEINS.
POLYMERIZATION MECHANISMS: CONDENSATION (ESTER AND AMIDE BOND); RADICAL ADDITION (POLY-ETHYLENE, POLY-PROPYLENE, POLY-METHACRYLATE). RADICAL INITIATION: CHEMICAL AND UVVIS. CONFORMATION AND CONFIGURATION. TACTILITY.
BIODEGRADABLE AND BIOCOMPATIBLE POLYMERS. BIODEGRADABLE SYNTHETIC POLYMERS: POLY-GLYCOLIC (PGA), POLY-LACTIC (PLA), POLY-LACTIC-CO-GLYCOLIC (PLGA), POLY-CAPROLACTONE (PCL). NATURAL POLYMERS: COLLAGEN, FIBRIN, ALGINATES, CHITOSAN. EXAMPLE OF PROSTHESIS AND ORTHODONTIC IMPLANTS.
AMORPHOUS, SEMI-CRYSTALLINE AND CRYSTALLINE POLYMERS. DEGREE OF CRYSTALLINITY, DEGREE OF POLYMERIZATION, MOLECULAR WEIGHT DISTRIBUTION. MEASUREMENT OF POLYMER MOLECULAR WEIGHT. MECHANICAL PROPERTIES OF POLYMERS, DEFINITION OF ELASTIC MODULUS AND STRESS-STRAIN CURVE. VARIATION OF THE PHYSICAL STATE AS A FUNCTION OF TEMPERATURE; DEFINITION OF GLASS TRANSITION AND SOFTENING TEMPERATURE.

	Teaching Methods
	LECTURES AND TUTORIALS

	Verification of learning
	WRITTEN AND ORAL EXAM

	Texts
	P. ATKINS, L. JONES, CHEMICAL PRINCIPLES: THE QUEST FOR INSIGHT. W.H. FREEMAN & CO. J. MC MURRY, FUNDAMENTALS OF ORGANIC CHEMISTRY. BROOKS/COLE, A CENGAGE LEARNING COMPANY J.M. BERG, J.L. TYMOCZKO, G.J. GATTO JR., L. STRYER, BIOCHEMISTRY. MCMILLAN. MATERIAL PROVIDED BY THE TEACHER FOR POLYMER SECTION